As a physician-scientist, I believe that we have the best chance of
impacting patient survival when scientists and physicians
work together to understand the biology of cancer and its
vulnerabilities, and to then translate this understanding from the bench to the bedside.
My own research focuses on cellular signaling pathways regulating
normal cell proliferation and differentiation, and how disruption of these
pathways can cause human diseases, especially cancer. I have a
particular interest in the biology and regulation of specific
molecules called
protein-tyrosine
phosphatases which are involved in many normal cell functions. I also study
the role of RAS/ERK pathway mutations in developmental diseases and
cancer, and the biology of breast and ovarian cancers.
I am a member of the
National Academy of Sciences,
the
American Academy of Physicians, and
the
Royal Society of Canada (Foreign Member).
Laura and Isaac Perlmutter Cancer Center at NYU Langone Medical Center
Director (2015 - 2023)
NYU School of Medicine
Professor, Department of Medicine (2015 - present)
Associate Dean for Cancer Research (2022 - 2023)
The Campbell Family Institute for Cancer Research, Toronto, ON
Founding Director (2008 - 2014)
Princess Margaret Hospital Cancer Center, Toronto, ON
Director, Research (2007 - 2014)
University of Toronto, Toronto, ON
Professor of Medical Biophysics (2007 - 2015)
Canada Research Chair, Tier 1 (2007 - 2015)
Beth Israel Deaconess Medical Center, Boston, MA
Deputy Director, Basic Research, Hematology/Oncology Division (2003 - 2007)
Director, Cancer Biology Program (1994 - 2007)
Harvard Medical School, Boston, MA
William B. Castle Professor of Medicine (2006 - 2007)
Professor of Medicine (1999 - 2007)
Associate Professor of Medicine (1993 - 1999)
Assistant Professor of Medicine (1988 - 1993)